General Information

  • ID:  hor005186
  • Uniprot ID:  P39089
  • Protein name:  Vasoactive intestinal peptide
  • Gene name:  VIP
  • Organism:  Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Didelphis (genus), Didelphinae (subfamily), Didelphidae (family), Didelphimorphia (order), Metatheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HSDAVFTDSYTRLLKQMAMRKYLDSILN
  • Length:  28(1-28)
  • Propeptide:  HSDAVFTDSYTRLLKQMAMRKYLDSILN
  • Signal peptide:  NA
  • Modification:  T28 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P39089-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P39089-F1.pdbhor005186_AF2.pdbhor005186_ESM.pdb

Physical Information

Mass: 379961 Formula: C146H234N40O44S2
Absent amino acids: CEGPW Common amino acids: L
pI: 9.12 Basic residues: 5
Polar residues: 8 Hydrophobic residues: 9
Hydrophobicity: -35 Boman Index: -5962
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 87.14
Instability Index: 3438.57 Extinction Coefficient cystines: 2980
Absorbance 280nm: 110.37

Literature

  • PubMed ID:  1542675
  • Title:  Isolation and amino acid sequences of opossum vasoactive intestinal polypeptide and cholecystokinin octapeptide.